Abstract
Objective To estimate the final stage parameters of blood coagulation – fibrinogen and D-dimer in patients with cystic fibrosis (CF). Methods 30 CF patients were enrolled. The comparison group included 17 children with congenital malformations of lung (CML). The level of fibrinogen and D-dimer in blood as well as fibrinogen gene polymorphism were studied. Results Level of fibrinogen in CF patients was significantly higher than in CML – 3.73 g/l vs 2.8 g/l (p = 0.018). Thrombophilic polymorphism of fibrinogen genes was identified in 43.4% of CF patients and in 30% of patients with CML (p Conclusion The changes of blood coagulation can indicate about increasing of plasma thrombogenic potential with the development of thrombosis. It is advisable to add antiplatelet agents to a complex therapy in CF patients.
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