Abstract
Background. Cord blood transplants (CBT) are associated with delayed or failed engraftment in a significant proportion of patients. Two of our previous observations suggested (i) that, in the animal model, direct intra-bone (i.b.) injection of hematopoietic cells improves seeding efficiency and (ii) that the delayed engraftment was not related to an insufficient number of hematopoietic stem cells but rather to a reluctance to differentiation and maturation. Methods. Unrelated CB (4/6 or 5/6 HLA antigen matched) were selected for 20 consecutive patients.
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