Abstract
Acute myeloid leukemia (AML) is the most common acute leukemia in adults and can be grouped based on recurrent genomic abnormalities with diagnostic and prognostic significance. Although cytogenetic characterization classically involves conventional chromosome and/or fluorescence in situ hybridization (FISH) assays, limitations to these labor-intensive techniques include poor resolution of chromosomes banding leading to the inability to precisely/completely identify breakpoints/gene content and difficulty visualizing cryptic rearrangements.
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