Abstract
UNLIKE proton nuclear magnetic resonance (NMR) spectroscopy, 13C NMR has the potential advantages in studies of macromolecular systems of a wider range of chemical shifts (∼200 p.p.m.) and of reduced resonance broadening in structures with restricted molecular motion. Thus we have been able to observe 13C NMR spectra of unsonicated lecithin and erythrocytes, which do not yield high resolution proton spectra. We also report T1 relaxation times for 13C nuclei in the polar headgroup of the lecithin molecule and at both ends of the alkyl chains, in sonicated vesicles in D2O buffer and in deuterochloroform. The results are consistent with increasing chain motion towards the terminal methyl group of the alkyl chains for both systems, in agreement with relaxation data for stearic acid derivatives specifically labelled with 19F nuclei in lecithin vesicles1, and with the results of similar spin label experiments of Hubbell and McConnell2.
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