Abstract
In the title compound, C30H31NO3S2, the piperidine ring adopts a distorted chair conformation. The thio-phene rings have twisted conformations about the C-C bonds. The mean plane of the piperidine ring makes a near orthogonal conformation with the toluene ring. Two of the phenyl rings in the structure are positionally disordered over two sets of sites with occupancies of 0.56 (2)/0.44 (2) and 0.672 (16)/0.328 (16). A region of disordered electron density was corrected for using the SQUEEZE [Spek (2015 ▸). Acta Cryst. C71, 9-18] routine in PLATON. The given chemical formula and other crystal data do not take into account the unknown solvent mol-ecule. In the crystal, O-H⋯O hydrogen bonds are observed along with intra-molecular S⋯H, O⋯H, C⋯H and H⋯H contacts.
Highlights
In the title compound, C30H31NO3S2, the piperidine ring adopts a distorted chair conformation
Two of the phenyl rings in the structure are positionally disordered over two sets of sites with occupancies of 0.56 (2)/ 0.44 (2) and 0.672 (16)/0.328 (16)
A region of disordered electron density was corrected for using the SQUEEZE [Spek (2015)
Summary
Many substituted piperidine derivatives possess a wide range of bioactivities (Pati & Banerjee, 2012). They find significant applications in drug development and their properties depend on the nature of the side groups and their orientations (Viswanathan et al, 2015). The piperidine ring adopts a distorted chair conformation as observed in a similar related structure, 2 {13-benzyl-4,11-dihydroxy-1,8-bis(4-methylphenyl)-2,9-dithia-13-azadispiro[4.1.47.35]tetradecan-6-one; Viswanathan et al, 2015}. Both the thiophene rings (rings D S2/C16/C15/C13/C17 and E: S1/C7/C10/C9/C8) have twisted conformations about the C—C bonds (C10—C9 in D and C13—C15 in E).
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