Abstract
OCD is a heritable multifactorial disorder, meaning that the risk of OCD is influenced by a combination of multiple genetic and environmental factors, such as maternal conditions before and during pregnancy. The maternal effect reflects influences on the offspring phenotype that result from indirect effects of maternal genotypes (maternal genetic nurture) and/or maternal environment; the former always, and the latter often, are beyond the direct influence of the mother herself. Despite the genetic and environmental findings for OCD, the contribution of inherited genetic variation across the allelic frequency spectrum and the contribution of maternal effect to the risk of OCD remains uncertain.
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