中樞性早熟女童血清中類胰島素因子-1,類胰島素因子結合蛋白-3 及瘦素濃度之相關性

Abstract

The puberty of the female begins around the age of 10~14 years of age. Meanwhile, the pulsatile secretion of gonadotropin-releasing hormone (GnRH) by hypothalamus signals the anterior pituitary to produce luteinizing hormone (LH) and follicle stimulating hormone (FSH) and stimulate the ovaries to produce estrogen and the maturation of ovarian follicles. There have been evidence in the literature suggesting that insulin-like growth factors-1（IGF-1）play a complex role of growth, differentiation and reproduction. In this article, the correlation of IGF-1 production and action on the gonadotropic axis during puberty will be investigated. However, the activity of IGF-1 is associated with insulin-like growth factor-binding proteins (IGFBPs) and leptin. In this study, thirty-eight girls with precocious puberty were enrolled in the study and thirty-eight prepuberty girls were studied as controls. The chronological age, bone age, body height, body weight, BMI, as well as the serum levels of FSH, LH, PRL, E2, IGF-1, IGFBP-3 and leptin by chemiluminescent immunoassay (CLIA) and radioimmunoassay (RIA) of each group were compared. By SPSS analysis, the result of t-test showed that there was significant increase in bone age, body height, body weight, BMI, IGF-1 and IGFBP-3 with precocious puberty girls (respectively; P<0.001). The Spearman concentration of serum IGF-1 is significantly correlated with chronological age, bone age, body height, FSH, LH and IGFBP3 in precocious puberty girls (p < 0.05; p < 0.01; p < 0.01; p < 0.01; p < 0.01; p < 0.01; respectively). And serum IGFBP-3 levels are significantly correlated with bone age, LH and IGFBP3 in precocious puberty (p < 0.05; p < 0.01; p < 0.01; respectively ). Serum leptin levels are associated with chronological age, bone age, body height, body weight and body mass index in precocious puberty girls (p < 0.01; respectively), and no correlation with IGF-1 and IGFBP-3. We thought that IGF-1 and IGFBP-3 play an important role of precocious puberty.