Abstract
12-Tungstosilicic acid supported on different metal oxides was used as catalyst in the synthesis of bis(indolyl)methanes via electrophilic substitution reactions of indole with structurally diverse aldehydes and cyclohexanone. The effects of solvent, catalyst loading, and the nature of substituents on the aromatic ring of aldehydes were investigated. The workup of the reaction consists of simple filtration, followed by concentration of the crude product, and purification. A mechanism for the catalytic activity is proposed, and corresponding products were obtained in good to excellent yields in relatively short reaction times. The catalysts were reusable without significant loss of activity.
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