Abstract
This study investigated the effect of extracted crude soybean saponins on preneoplastic lesions, aberrant crypt foci (ACF), and the related inhibitory mechanism of extracted crude soybean saponins. Rats assigned into five groups according to different doses of extracted crude soybean saponins and received 1,2-dimethylhydrazine (DMH) injection in week 5. In week 15, all rats were sacrificed. The number of ACFs, the cyclooxygenase-2 (COX-2) protein expression, the level of prostaglandins E2 (PGE2) and the activity of β-glucuronidase were examed. Results revealed that the consumption of extracted crude soybean saponins decreased the number of ACFs and the activity of β-glucuronidase in rats, while did not affect the COX-2 protein expression and PGE2 level. In conclusion, extracted crude soybean saponins decreased the number and size of ACFs. The mechanism may be correlated to the activity of β-glucuronidase in colonic mucosa but not the COX-2 protein expression and PGE2 level.
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