1299 RELATION BETWEEN AORTIC PULSE WAVE VELIOCITY AND POSTPRANDIAL HYPERTRIGLYCERIDEMIA IN NONALCOHOLIC FATTY LIVER DISEASE

Abstract

Background and Aims: It is well known that Non-alcoholic Fatty Liver Disease (NAFLD) patients have increased coronary heart disease (CHD) risk. On the other hand, CHD risk of fatty liver patients other than NAFLD has not been well estimated. We aimed to assess CHD risk of fatty liver patients with significant alcohol consumption. Methods: Individuals who underwent a voluntary general health examination at konkuk university health care center were recruited and framingham risk score (FRS) was used for comparing CHD risk. Fatty liver was diagnosed according to abdominal image such as ultrasonography or computed tomography. NAFLD was defined as image finding of fatty liver and a level of alcohol consumption <140g/week in male and <70g/week in female. Alcohol consumption over this amount was defined as significant alcohol consumption. Results: A total 9,935 individuals were included after exclusion of other chronic liver diseases such as hepatitis B or hepatitis C. The mean FRS was different between normal group and fatty liver group (−0.17 vs. 2.62, p < 0.001). The mean estimated 10 year CHD risk (3.2% vs. 4.3%, p < 0.001) and the rate of individuals with over 10% CHD risk (2.6% vs. 4.3%, p < 0.001) were also different between two groups. Among individuals with fatty liver, NAFLD group showed higher FRS than fatty liver group with significant alcohol consumption (2.8 vs. 2.4, p = 0.004). The mean estimated 10 year CHD risk (4.5% vs. 4.0%, p < 0.001) and the rate of individuals with over 10% CHD risk individuals (5.7% vs. 2.4%, p < 0.001) were also higher in NAFLD group Conclusions: Individuals with fatty liver have an elevated CHD risk. Individuals with fatty liver and significant alcohol consumption showed lower FRS than NAFLD.