1297 FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY FOR PREOPERATIVE STAGING AND POSTOPERATIVE FOLLOW-UP OF UROTHELIAL CARCINOMA

Abstract

You have accessJournal of UrologyBladder Cancer: Detection & Screening1 Apr 20131297 FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY FOR PREOPERATIVE STAGING AND POSTOPERATIVE FOLLOW-UP OF UROTHELIAL CARCINOMA Anwar Alesawi, Andre Caron, Alain Bergeron, Helene Hovington, Vincent Fradet, Louis Lacombe, and Yves Fradet Anwar AlesawiAnwar Alesawi Quebec, Canada More articles by this author , Andre CaronAndre Caron Quebec, Canada More articles by this author , Alain BergeronAlain Bergeron Quebec, Canada More articles by this author , Helene HovingtonHelene Hovington Quebec, Canada More articles by this author , Vincent FradetVincent Fradet Quebec, Canada More articles by this author , Louis LacombeLouis Lacombe Quebec, Canada More articles by this author , and Yves FradetYves Fradet Quebec, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2651AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The treatment and prognosis of bladder cancer depends on lymph node involvement in addition to other factors, but the accuracy of conventional imaging modalities for the prediction of nodal involvement or even detection of recurrence in early stage is limited. This study retrospectively investigated the value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in the staging and follow up of urothelial carcinoma in comparison to contrast-enhanced computed tomography (CT). METHODS We reviewed 148 files of urothelial carcinoma patients. Of these, 134 had initial and 80 had follow-up PET/CT scans while 103 patients had initial and 82 had follow-up CT scans. Initial CT and PET/CT results were correlated with histopathology data (grade, stage and lymph node status). Follow-up CT and PET/CT results were confirmed by repeated imaging studies. RESULTS The sensitivity for detecting lymph node metastasis before surgery was 43.39% vs 43.58% while the specificity was 100% vs 95.23% for PET/CT scan vs CT scan, respectively. PET/CT scan had higher specificity in detecting recurrence (97.87% vs 90.19%) with higher positive predictive value (96.97% vs 85.7%). There was a significant association between recurrence discovered by PET/CT scan and the nodal status as 86.7% of patients who developed recurrence had positive lymph node whereas 13.3% had negative lymph node at surgery (p<0.0001, chi square). In addition, stage status at surgery was significantly associated with PET/CT scan discovered recurrence as 86.7% of patients who developed recurrence were ≥pT3 while 13.3% were ≤pT2 (p<0.005, chi square). CONCLUSIONS PET/CT scan is not inferior to CT scan in detecting positive lymph nodes before surgery of urothelial cancers while it is superior to CT scan in detecting recurrence after surgery. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e530 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anwar Alesawi Quebec, Canada More articles by this author Andre Caron Quebec, Canada More articles by this author Alain Bergeron Quebec, Canada More articles by this author Helene Hovington Quebec, Canada More articles by this author Vincent Fradet Quebec, Canada More articles by this author Louis Lacombe Quebec, Canada More articles by this author Yves Fradet Quebec, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...