1293-P: Diagnosing GDM in the Indian Population with Country-Specific Glucose Cut-Off Values

Abstract

Introduction: In India, about 5 million pregnancies are affected with gestational diabetes mellitus (GDM), which triggers unfavourable pregnancy outcomes. Infants that experience intrauterine hyperglycemia are more likely to develop obesity and diabetes. Insulin resistance is associated with the Indian phenotype's propensity to accumulate excessive central fat. This study aimed to ascertain how different plasma glucose concentrations affected the ability of participants in an Indian birth cohort to predict unfavourable outcomes for both mothers and babies. Methods: We looked at a prospective cohort of pregnant women in public hospitals in Bihar, India. Pregnant women between 24 and 36 weeks underwent a 2-hour 75g oral glucose tolerance test. Following delivery, we measured the skinfold thickness of infants at the biceps, triceps, and subscapular regions of the body. For predicting the risk of SSFT new-borns and caesarean deliveries with the FBS and PPBS, 240 reliable Poisson models were built. FBS≥87 up to 92 mg/dL and PPBS≥134 up to 153 mg/dL with a one-unit increase were tested with sum of skinfold thickness (SSST) and C section delivery. Results: We discovered that 46.91% of the mothers underwent caesarean sections, and 10.65% of the new-borns had SSFT. Results show that after correcting for age, parity, socioeconomic status, height, and maternal obesity, FBS87 mg/dL and PPBS of 134 mg/dl were linked with risk of higher SSST in new-borns and caesarean delivery. Conclusion: In India, pregnant women are more likely to experience negative birth outcomes due to lower glucose cut-off readings than in other international classification systems. These results provide information for revising the cutoff points in light of the contextual conditions in LMIC nations. Disclosure S.C.Jha: None. N.Kumar: None.