Abstract
was confirmed by histopathological examination. Results: Expression of IA in transduced antigen-presenting cells (APCs) from CBA mice, promoted operational tolerance to B6 hearts which showed no sign of cardiac allograft vasculopathy. Control third party transplants as well as B6 hearts implanted in GFP-treated CBA mice were rejected with a mean survival time 20 days. In contrast, genetic matching for IA between B10.A(5R) donor and B6 recipient mice treated with anti-CD8, led to delayed acute rejection of heart grafts (84 31.9 days). Conclusions: Results indicate that contrary to genetic MHC II matching, somatic MHC II matching via IA gene transfer in bone marrow, leads to immune tolerance. Given that: 1) it is known that thymic medulla includes bone marrow-derived APCs and 2) we previously demonstrated that IA gene transfer induced IA-specific regulatory T cells (T-regs), we suggest that selective IA expression in thymic medulla favors T-reg differentiation/activation in this model.
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