129 Evaluation of the effect of Bedoukian compound X administered twice on gastrointestinal nematode infection in sheep

Abstract

Abstract Gastrointestinal nematodes (GIN) and coccidia have a large financial and health impact on small ruminants. Recent years have seen an increase in anthelminthic/ coccidiostat resistance, and there is a need to develop alternative control methods. The objective of this study was to examine the effect of a unique proprietary compound used in the fragrance/flavor industry with an insect repellant application (Compound X; Bedoukian Research) on parasite control in sheep. Previous research by our laboratories showed a short term reduction in fecal egg count (FEC) in sheep orally drenched with the product. In the current study, naturally infected (GIN and coccidia) Katahdin lambs were orally drenched with 15 mL of Compound X and 15 mL mineral oil (CMX; n = 11) or 30 mL mineral oil (CON; n = 9) on d 0 and 21; FEC/fecal oocyst count (FOC) were determined every 7 d for 8 wk, and feces were cultured to examine GIN larvae. Data were analyzed using a mixed model with repeated measures over time, and regression (SAS). The FEC were reduced in CMX compared with CON between d 0 and 21 (P < 0.03, both mixed model and regression), d 21 and 42 (P < 0.001, mixed and regression), and d 0 and 56 (P < 0.001); FEC were influenced by day of study (P < 0.04), and the interaction tended to be significant using regression (P < 0.10). The FOC were negligible and not analyzed. There was no effect on development of nematode larvae in feces. However, there was a shift in population distribution from Haemonchus contortus to Trichostrongylus spp. which indicated a possible effect on female H. contortus fecundity. There was a sign of toxicity in one lamb following the second CMX drench. The value of using such a compound for GIN control may warrant further investigation.