1286 Structure-based prediction of neoantigens paired with T cell receptors on phenotype-selected CD8+ tumor-infiltrating lymphocytes

Abstract

BackgroundVaccination by tumor neoantigens are promising immunotherapy by providing more tumor-reactive T cell pool, which could be boosted by anti-PD-1. Identification of neoantigens cognate to tumor-reactive tumor-infiltrating lymphocytes (TILs) is...