12829 Mycophenolate mofetil for lichen planopilaris: Systematic review and meta-analysis

Abstract

Background: Lichen planopilaris (LPP) is a type of primary cicatricial alopecia, a cutaneous disorder which selectively affects hair follicles via a lymphocytic inflammatory process. Although a rare condition, it is the most common form of adult primary scarring alopecia and has a significant detrimental impact on self-confidence and quality of life. Most patients are initially treated with hydroxychloroquine, however for those who fail this, there are currently few other options available. Mycophenolate mofetil (MMF) is an antimetabolite used in preventing organ transplant rejection and specifically inhibits activated lymphocytes.