128 Transcriptional profiling of Blaschko-linear psoriasis skin highlights mostly shared but occasionally divergent features with psoriasis vulgaris

Abstract

Psoriasis may very rarely manifest along the lines of Blaschko. We assessed gene expression in 2 individuals with Blaschko-linear psoriasis (BLP) and compared genes and pathways with their non-lesional skin as well as public repository psoriasis vulgaris (PV) skin data. By undertaking differential expression analysis between lesional and non-lesional BLP skin samples, we identified 763 differentially expressed (DE) genes (adjusted P<0.1). To assess pathway enrichment, we performed gene ontology (GO) and gene set enrichment analysis (GSEA).