Abstract
Catechol O-Methyltransferase (COMT) is an enzyme which degrades catecholamines, including epinephrine, norepinephrine, and dopamine. A common functional polymorphism of the COMT gene (Val 158Met) decreases COMT thermostability, resulting in a 3-4 fold reduction in COMT enzyme activity. The allelic affects are codominant, so that individuals with the met/met genotype have the least COMT enzyme activity. In animal models, it has previously been shown that heightened catecholamine levels increase pain sensitivity.
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