127 Sensitive skin protection by strengthening the skin barrier with a LCE6A biomimetic green peptide specific to the cornified envelope

Abstract

The skin is exposed to environmental aggressions and its stratum corneum (SC) plays a role in the barrier function (BF) which is critical for skin homeostasis. The maintain of this BF is important to avoid exogenous pathogen penetration and skin inflammation leading to the risk of developing allergic disease as atopic dermatitis (AD). Proteins of the Late Cornified Envelope (LCE) family are constitutive components of the cornified envelope (CE), a SC structure essential for the BF. We have developed a biomimetic green peptide corresponding to a specific sequence of the LCE family member LCE6A.