Abstract
Tissue resident memory (Trm) CD8 + T cells are a newly described memory T cell populations that are distinct from circulating memory T cells. The Trm CD8 + T cell responses are critical for protection against pathogens that invade the host via skin and mucosal tissues. Transforming growth factor- β eta (TGF- β eta) is thought to be important for controlling the numbers of KLRG + effector T cells and promoting the residence of the Trm CD8 + T cells in several nonlymhpoid tissues including intestine. We will present data on how TGF- β eta signaling differentially regulates circulating and tissue resident memory CD8 + T cells after systemic infection with Listeria monocytogenes in mice.
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