Abstract
The Rho-associated protein kinase (ROCK) is responsible for the regulation of cell adhesion, shape and migration by altering cytoskeletal structure. The ROCK inhibitor, Y27632, protects cells from anoikis and enhances embryonic stem cell viability in culture and cryopreservation. Y27632 prolongs the life span of cultured primary mouse keratinocytes. Oncogenic RAS transduced primary mouse keratinocytes (RAS-keratinocytes) become senescent in vitro. Here, we show that chronic treatment of Ras transduced primary mouse keratinocytes (RAS-keratinocytes) with Y27632 reduces the number of senescence associated β-galactosidase positive cells which are flat and enlarged.
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