Abstract
Extracorporeal membrane oxygenation (ECMO) might alter the cerebral hemodynamics. Using near infrared spectrophotometry (NIRS) concentration changes of oxyhemoglobin (ΔcO2Hb), deoxyhemoglobin (ΔcHHb) and total hemoglobin (ΔctHb) in cerebral tissue were measured during induced hypercapnia and hypocapnia in 4 groups of 6 anesthetized, paralysed and mechanically ventilated piglets: Gr.1: normoxemic, Gr.2: hypoxemic, Gr.3: ECMO after normoxemia, Gr.4: ECMO after hypoxemia. ΔcO2Hb and ΔcHHb reflect changes in cerebral O2 supply, while ΔctHb reflects changes in cerebral blood volume (CBV). Intracranial pressure (ICP) was also measured.No significant differences between groups were found, with exception of ΔcO2Hb and ΔcHHb in Gr.4 during hypocapnia.Conclusion; The influences of CO2 changes on cerebral oxygenation and hemodynamics are not altered during ECMO.
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