126P Clonal architecture and genomic features of smoking versus non-smoking oncogene-driven East-Asian non-small cell lung cancer

C-Y Huang,N Jiang,M Shen,G Lai,A Takano,T.K.H Lim,W.L Tam,A Skanderup,D.S.W Tan,S.G Rozen

doi:10.1016/j.annonc.2022.09.127

126P Clonal architecture and genomic features of smoking versus non-smoking oncogene-driven East-Asian non-small cell lung cancer

C-Y Huang, N Jiang + Show 8 more

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https://doi.org/10.1016/j.annonc.2022.09.127

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Journal: Annals of oncology : official journal of the European Society for Medical Oncology	Publication Date: Oct 1, 2022
License type: publisher-specific-oa

Affiliation: Duke-NUS Medical School, National Cancer Centre Singapore, Singapore General Hospital, Genome Institute of Singapore, Agency for Science, Technology and Research

#Non-small Cell Lung Cancers #Complex Genomic Landscapes + Show 8 more

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Abstract

Unlike smoking-related lung cancers, oncogene-driven non-small cell lung cancers (NSCLC) are characterized by low mutational burden and complex genomic landscapes. In East Asia, ∼30% of patients with EGFR-driven NSCLC have a history of smoking. This study aims to investigate the impact of tobacco exposure on clonal architecture of EGFR-mutant NSCLC.

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