Abstract
Background: Type 2 diabetic nephropathy (T2DN) is one of the most common chronic microvascular complications of type 2 diabetes (T2DM). Researchers found that free fatty acids(FFA) is an independent risk factor for vascular complications of T2DM. It is particularly important to analyze whether the changes in the metabolic spectrum of FFA is associate with the development of T2DN in diabetic patients.Method: 612 subjects were enrolled in the present study in Dalian, a city in Northeast China. The study population consisted of 51 T2DN, 108 T2DM, and 453 healthy individuals. 23 kind of serum FFAs including docosahexaenoic acid(DHA, C22:6), nervonic acid (C24:1) were measured by LC-MS technology.Result: The levels of nervonic acid and DHA are significantly lower in T2DN group when compared to the healthy control group. Multi-factor Logistic regression analysis shows that nervonic acid (OR 95% CI:0.943 (0.890 ~0.999), p<0.05), DHA (OR 95% CI:0.983 (0.968~0.998), p<0.05) may act as protective factors in patients with T2DN.Conclusion: The present study found that the content of neuronic acid and DHA in T2DN patients is relatively low, which indicates that neuronic acid and DHA may have protective effects on T2DN. Hence, this study provides a new idea for potential clinical intervention and supplementation of exogenous FFAs for the prevention and treatment of T2DN.View largeDownload slideView largeDownload slide DisclosureY. Liu: None. Y. Li: None. M. Zhou: None. X. Xia: None. H. Shen: None. Y. Li: None. Y. Xu: None. C. Han: None.
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