1263 SEARCH OF AN IDEAL SOLUTION FOR THE PRE-IMMERSION OF TITAN® PENILE IMPLANT AND COMPARISON WITH INHIBIZONE

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Peyronie's Disease/Surgical Therapy II1 Apr 20101263 SEARCH OF AN IDEAL SOLUTION FOR THE PRE-IMMERSION OF TITAN® PENILE IMPLANT AND COMPARISON WITH INHIBIZONE Chirpriya Dhabuwala, Andrew Kumar, Anthony John, and Atul Rajpurkar Chirpriya DhabuwalaChirpriya Dhabuwala Bloomfield Hills, MI More articles by this author , Andrew KumarAndrew Kumar Bloomfield, MI More articles by this author , Anthony JohnAnthony John Miami, FL More articles by this author , and Atul RajpurkarAtul Rajpurkar Pontiac, MI More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.821AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Surface treatment of penile implants is an important tool in reducing penile implant infection. It is a common practice to immerse the Titan implant in antibiotic solutions e.g. vancomycin, bacitracin etc. prior to implantation. The choice of this solution however has not been scientifically evaluated. Objective: In the present work we have studied the zones of inhibition for titan implant strips immersed in different antibiotics in an attempt to identify an ideal solution for immersing the Titan implant prior to implantation. METHODS Materials: Titan strips: Five Titan 0.5 cm. X 1.0 cm. were dipped in each of the five following solutions. Solution 1 Rifampin 10mgm/ml; Gentamycin 1mgm/ml Vancomycine 2mgm/ml. Solution 2 (R10/G1) Rifampin 10mgm/ml; Gentamycin 1mgm/ml. Solution 3 Rifampin 1mgm/ml; Gentamicin 1mgm/ml, Vancomycine 2mgm/ml. Solution 4 (R1/G1) Rifampin 1mgm/ml; Gentamycin 1mgm/ml. Solution 5 Rifampin alone 10mgm/ml. Solution 6 Bacitracin 50 units/ml; Gentamycin 1 mgm/ml; Control (C) Normal saline. Methods: A zone of inhibition was measured against Staph. Epidermidis and E. coli. A similar zone of inhibition was also studied for five Inhibizone strips for comparison. RESULTS Table 1, Table2. Table 1. describes the zones of inhibition results for Titan strips. Staph epidermidis E. coli Zone of Inhibition (mm) Zone of Inhibition (mm) Solution 1 47 20 Solution 2 (R10/G1) 47 20 Solution 3 44 20 Solution 4 (R1/G1) 42 20 Solution 5 50 16 Solution 6 30 30 Control (C) 0 0 Table 2. Compares the zones of inhibition between Titan dipped in R10/g1, R1/G1 and Inhibizone Titan Silicone Solution 2 (R10/G1) Solution 4 (R1/G1) Control C Inhibizone R/M Control Staph epidermidis 47 42 0 30 0 E. coli 20 20 0 15 0 CONCLUSIONS Both the rifampin based solutions R10/G1 and R1/G1 have an excellent coverage against Staph. Epidermidis and E. coli. The zone of inhibition produced by both these solutions exceeds that produced by Inhibizone by 40% to 56% for Staph. Epidermidis and 33 % for E. coli. Based upon the present study it appears that coating the Titan implant with R10/G1 solution provides an excellent coverage against Staph epidermidis and E. Coli. In clinical practice Use of R10/G1 to coat Titan implant has resulted in 0 infection in 116 consecutive penile implant surgeries. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e489 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Chirpriya Dhabuwala Bloomfield Hills, MI More articles by this author Andrew Kumar Bloomfield, MI More articles by this author Anthony John Miami, FL More articles by this author Atul Rajpurkar Pontiac, MI More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...