Abstract
Crizotinib as an ALK/ROS1/MET inhibitor, is highly effective against ROS1-rearranged lung cancer. However, similar to other oncogene-driven lung cancers, ROS1-rearranged lung cancers treated with crizotinib eventually acquired resistance. In our study, we examined the profiles of ROS1 resistance mutations and co-occurring genetic alterations after crizotinib treatment.
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