Abstract
The role of event-related evoked potentials (ERPs) in multiple sclerosis (MS) is controversial. Previously we found P300 abnormalities (increased latency and lower amplitude) related with attention and executive functions in advanced MS patients. Our aim was to evaluate possible impairment of P300 in early stages of disease related to cognitive dysfunctions. We recruited 11 patients (mean age 33.5 ± 8.1 years, EDSS 2 ± 1.1). Registration of ERPs was performed by random double auditory discrimination task paradigm and recorded through scalp electrodes placed at Fz, Cz and Pz and linked to the referred ears. RAO battery was used to examine patients cognitive functions. Spearman test was used to evaluate correlation between neurophysiologic and neuropsychological parameters. No significant change in P300 parameters compared to reference values of our laboratory normalized to age and gender stratified population. Neuropsychological Tests showed mild alterations in procedural memory and attention functions not statistically correlating with a non significant reduction in amplitude of P300 in only 2 cases. Despite the limited MS-cohort we find it useful to undergo ERP and neuropsychological tests in MS early phases to identify subclinical cognitive impairment possibly present in a small percentage of cases.
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