Abstract
CXCL8 is a neutrophil chemotactic factor (Nph), which is a key effector cell of innate immunity and plays a crucial role in various inflammatory diseases. CXCL8 regulates pathological angiogenesis, tumor growth and metastasis and enhances the protumor effect of Nph (Gonzalez-Aparicio M., 2020). At the same time, protumor Nph (N1) are characterized by reduced expression of chemokines (Sagiv J.Y., 2015). The study was aimed at assessing the expression of the CXCL8 gene by circulating Nph and the serum level of CXCL8 at different stages of clear cell kidney cancer.
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