Abstract
Background: Valproic Acid (VPA) is a histone deacetylase (HDAC) inhibitor found to prolong survival of rats in hemorrhagic shock when given as pretreatment. In this study we test whether the post-hemorrhage administration of VPA with small volume resuscitation would induce histone hyperacetylation and inflammatory modulation in a lethal swine hemorrhagic shock model. Methods: Anesthetized Yorkshire swine were subjected to lethal hemorrhagic shock using standard iliac vessel injuries with uncontrolled bleed for 15 minutes (average blood loss of 40% Total Blood Volume, TBV).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
