124 Xe 가스 재활용 공정장치 및 123 I 회수 시스템 구현 및 성능검증

Abstract

123 I is a crucial nuclide used in the production of radiopharmaceuticals, particularly for diagnosing thyroid cancer and creating various labeled compounds. The demand for 123 I is increasing annually, leading to a rise in 123 I production. 123 I is generated through cyclotron-based beam irradiation of 124 Xe gas. However, transporting high-purity 124 Xe gas in Dewar containers can result in gas loss due to temperature and pressure variations during transit. To address this challenge, we have developed a system aimed at minimizing 124 Xe gas loss and efficiently recycling the used 124 Xe. Given the costliness of 124 Xe gas, effective management is essential. Additionally, ensuring the safe and loss-free transfer of the produced 123 I to the designated column is paramount. We have implemented a cleaning system utilizing high-purity helium and a heater to prevent pipeline contamination after production. This paper discusses the strategies employed in the design, manufacturing, and trial operation of GPM, HCS, and WPM. Through these measures, we have succeeded in significantly reducing 124 Xe loss and minimizing residual 124 Xe and 123 I with in the pipelines. The result is a highly efficient radiopharmaceutical production system.