Abstract
Circadian rhythm in psoriatic skin has been studied in vitro and in vivo animal experiments. However, its human cellular implications are less well known. Epidemiological data have shown that psoriasis is more common among shift workers. We investigated the expression and daily rhythm of clock genes and proteins in psoriatic skin biopsies and HaCaT keratinocytes after stimulation with cytokines (TNFα, IL-23, IL-22, IL-1β, IL-17A). Clock, bmal1, cry1, per1, per2 and rev-erbα circadian genes and cop1 and mdm2 cell cycle regulators were examined in mRNA expression experiments.
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