Abstract
The oxytocin/oxytocin receptor (OT/OTR) system has been reported to influence a variety of physiological, behavioural, and emotional processes in humans. There are a wide range of studies focusing on their role in parturition, lactation and behaviour. More recent studies have investigated the novel effects of OT/OTR system including inflammation and miRNAs, as well as the effect of their genetic polymorphisms on the onset of labour and parturition. OT also appears to have a great influence in cardiomyocyte differentiation and heart homeostasis, and an age-specific regulation of muscle maintenance and regeneration. This review will summarize the previously established role of OT/OTR system as well as the studies on their novel roles, and highlight the potential therapeutic approaches.
Highlights
The medicinal chemists have considered the synthesis of 1, 2, 3-triazole based heterocycles as the corner stone of medicinal chemistry due to their important biological activities
The copper(I)-catalyzed azidealkyne cycloaddition (CuAAC) approach has been widely used in the different spheres of the science such as bioconjugation [9], oligonucleotide synthesis [10], construction of bolaamphiphilic structures [11], DNA labelling [12] and drug discovery [13]
Haider et al have synthesized a library of benzoxazolinone based 1, 2, 3-triazoles using click chemistry approach and screened them for their in vitro and in vivo anti-inflammatory activity
Summary
The medicinal chemists have considered the synthesis of 1, 2, 3-triazole based heterocycles as the corner stone of medicinal chemistry due to their important biological activities. Haider et al have synthesized a library of benzoxazolinone based 1, 2, 3-triazoles using click chemistry approach and screened them for their in vitro and in vivo anti-inflammatory activity. Assis et al have synthesized 1, 2, 3-triazole based phthalimide derivatives by the 1,3-dipolar cycloaddition reaction of N-(azido-alkyl)phthalimides with terminal alkynes and screened them for their anti-inflammatory activity.
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