Abstract
Experimental autoimmune encephalomyelitis (EAE) is a pre-clinical disease model of Multiple Sclerosis (MS). In the present study we used a novel emulsion derived from the spinal cord – spinal cord homogenate (SCH) – to induce disease in Dark-Agouti (DA) rats, monitoring EAE course by using Visual Evoked Potentials (VEPs) to assess their usefulness as neurophysiological biomarker. 19 DA rats were used in the experiment: 7 immunized by injecting SCH (EAE RATS) and 12 controls (CTRL RATS). Flash epidural VEPs from both eyes were recorded 6 times once a week (first one the day before, then at days 6, 13, 20, 27, 34 post immunization). We measured P1 latency and amplitude from N1–P1–N2 complex by acquiring, for each session, the average of 4 waveforms (10 trains each) from each eye. There was significant difference in P1 latency between CTRL RATS and EAE RATS at days 13–20 and 27 post immunization ( p p > 0,05). The present results reveal that VEP P1 latencies are significantly delayed in EAE RATS, thus showing that VEPs could be a useful tool in monitoring disease course also in this new EAE animal model.
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