Abstract
Background: Immune checkpoint inhibitors (ICIs) have recently become a major strategy in treatment of non-small cell lung cancer (NSCLC), but somatic mutations involving the STK11 and KEAP1 genes may elicit resistance to anti-PD(L)1 agents. We conducted a systematic review aiming to determine if these mutations are significantly related to poorer outcomes in NSCLC patients (pts) treated with ICIs.
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