1223-P: CRP-Mediated Associations of the Individual and Neighborhood Stressors with T2D in the MESA Cohort

Abstract

There has been growing interest in examining the link between individual/neighborhood stressors with T2D. Prior studies have not tested if inflammation (CRP) may mediate the associations between multi-level stressors and T2D. This study included baseline data from the Multi-Ethnic Study of Atherosclerosis (MESA; n=5405; age=61.9±10.1y; 52% female) . T2D was defined as FPG ≥126 mg/dL or the use of diabetes drugs. Individual stressors included perceived lifetime discrimination, chronic burden, and personal safety. Neighborhood stressors included perceived problems, social cohesion, and physical activity facility density. Log transformed CRP (mg/L) was tested as the potential mediator. Linear regression models were used to test for significant indirect effects, adjusting for covariates. Twelve percent of participants (n=650) had T2D. Chronic burden and physical activity facility density were indirectly related to T2D via CRP (Table) . That is, higher chronic burden and lower density of physical activity facilities were linked to higher CRP. In turn, higher CRP was positively associated with T2D. Other stressors were neither directly nor indirectly associated with T2D. The associations between these stressors and T2D appear to be mediated by higher CRP in the MESA cohort. Future research should test the longitudinal mediating role of inflammation on the associations of stressors on T2D. Disclosure K.Tamura: None. R.Jagannathan: None. L.Hu: None. S.Neally: None. Y.Baumer: None. K.Narayan: n/a. V.Vaccarino: None. T.Powell-wiley: None.