Abstract
Germline mutations in the ataxia telangiectasia mutated (ATM) gene occur in 0.5-1% of the overall population and are associated with tumour predisposition. The clinical and pathologic features of ATM-mutated prostate cancer (PC) have not been well defined. Data suggest that they are associated with poor prognosis PC. Herein, we examine our cohort of sequenced mCRPC for germline ATM mutations in patients with advanced PC, and report on associated clinical features.
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