1218-P: Inflammatory Biomarkers Associate with Incident Metabolically Unhealthy Obesity: The CARDIA Study

Abstract

Background: The presence of cardiometabolic risk factors in obesity, termed metabolically unhealthy obesity (MUHO), confers a ten-fold increased risk of type II diabetes (T2DM). The components of MUHO may originate in inflammatory and/or oxidative stress pathways. Yet, biomarkers within these pathways have rarely been explored to associate with incident MUHO. We examined relationships of adiponectin, c-reactive protein (CRP), and uric acid with incident MUHO over 15-years.Methods: A total of 292 participants with obesity and ≤ 2 cardiometabolic risk factors from the CARDIA study (years 2000-2015) were included. MUHO was defined by the presence of ≥ 2 ATPIII metabolic syndrome criteria at 5, 10 and 15 year follow-up. Multilevel logistic regression controlled for age, sex, race/ethnicity. Secondary models examined relationships between biomarkers and each component of cardiometabolic risk.Results: Results are provided in Table 1. A 4.9 pg/mL increase in adiponectin (+1SD) was associated with lower incidence of MUHO, HDL-C, and glucose. A 1.4 mg/mL increase in uric acid (+1SD) associated with incident metabolically unhealthy obesity and individual cardiometabolic risk factors. No significant associations were found with CRP.Conclusions: Adiponectin and uric acid could help identify individuals with obesity at risk for developing MUHO and offer the opportunity to initiate preventive measures.View largeDownload slideView largeDownload slide DisclosureL. M. L. Corso: None. C. E. Lewis: None. M. R. Carnethon: None. S. M. Camhi: None. T. Huedo medina: None. J. Mccaffery: None.