1217 DEFINING GOLD STANDARD MEASURES FOR ERECTILE DYSFUNCTION IN PROSTATE CANER PATIENTS

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation1 Apr 20101217 DEFINING GOLD STANDARD MEASURES FOR ERECTILE DYSFUNCTION IN PROSTATE CANER PATIENTS Alexandra Berk, John Mulhall, and Christian Nelson Alexandra BerkAlexandra Berk More articles by this author , John MulhallJohn Mulhall More articles by this author , and Christian NelsonChristian Nelson More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.719AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Erectile dysfunction (ED) is common in prostate cancer (PC) patients across a range of treatment modalities. It is therefore essential that a gold standard be established for measuring ED in this population. This study defines which ED measures have been properly validated in PC patients by examining their measurement properties against FDA validation standards for patient reported outcomes (PRO's). METHODS A PubMed search using keywords “assessment” and “erectile” OR “male sexual function” identified measures that had a validation publication in English. Excluded were measures which solely assessed quality of life or other psychological constructs associated with ED. Once the measures were identified, the validation procedures for each were compared against the FDA's guidelines for the development of PRO's. We investigated validation data in a general ED population and in PC. RESULTS Eight measure were identified: The Erection Hardness Score (EHS), International Index of Erectile Function (IIEF), Men's Sexual Health Questionnaire (MSHQ), Quality of Erection Questionnaire (QEQ), Sexual Experience Questionnaire (SEX-Q), Sexual Health Inventory for Men (SHIM), UCLA Prostate Cancer Index (PCI), and the Expanded Prostate Cancer Index Composite (EPIC, an expanded version of the PCI) All of the measures were developed using input from experts, patients, and literature reviews with the exception of the EHS, a single-item measure. The only measure that utilized cognitive interviewing was the MSHQ. In a general ED population, most of the scales reported test-retest reliability coefficients and Cronbach's alpha values of at least 0.65, with the majority being over 0.7. The SHIM was the only measure that did not provide any reliability statistics. The only scale that reported assessing content validity was the UCLA-PCI. Almost all of the scales reported convergent validity with other erectile dysfunction measures. The majority of scales were multidimensional and assessed both function and bother. Of the 8 measures examined, only 3 were specifically validated in a PC population: the IIEF, the PCI, and the EPIC. CONCLUSIONS The majority of ED measures follow acceptable item development practices, are multi-dimensional, and report good psychometric properties. However, few measures have been specifically validated in a PC sample. The IIEF and UCLA-PCI/EPIC are the most extensively validated measures for use in PC patients. New York, NY© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e471 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alexandra Berk More articles by this author John Mulhall More articles by this author Christian Nelson More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...