1215 DO UROLOGIC PROCEDURES SUCH AS PROSTATE NEEDLE BIOPSY AND VASECTOMY CAUSE ERECTILE DYSFUNCTION?

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation1 Apr 20101215 DO UROLOGIC PROCEDURES SUCH AS PROSTATE NEEDLE BIOPSY AND VASECTOMY CAUSE ERECTILE DYSFUNCTION? Dan Lewinshtein, Jason Kim, Stephen Lukasewycz, and Christopher Porter Dan LewinshteinDan Lewinshtein More articles by this author , Jason KimJason Kim More articles by this author , Stephen LukasewyczStephen Lukasewycz More articles by this author , and Christopher PorterChristopher Porter More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.717AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prior studies suggest that prostate needle biopsy (PNB) and vasectomy may cause erectile dysfunction (ED). We explored the relationship between a prior PNB or vasectomy and rates of ED. METHODS We reviewed a prospectively organized database of 890 patients who underwent transrectal ultrasound (TRUS)-guided PNB. ED was modeled as a categorical variable as either any, moderate-severe, or severe based on International Index of Erectile Function (IIEF) scores. Binary logistic regression was used to evaluate the predictive ability of PNB and vasectomy. They were adjusted for age in multivariate analysis.IIEF scores were obtained prior to each biopsy procedure. RESULTS Median age and IIEF score were 63 years and 19 points, respectively. According to IIEF scores, 22%, 11%, 15%, 34% had severe, moderate, mild-moderate, and mild ED, respectively. 18% had no ED. Vasectomy status was available in 391 patients, of whom 41% had prior vasectomy. On univariate analysis, age (OR=1.1, p<0.001), prior PNB (OR=1.83, p<0.002) and prior vasectomy (OR=0.41, p<0.001) were all associated with moderate-severe ED. Only age (OR=1.1, p<0.001) and vasectomy (OR=0.39, p<0.002) were predictive for severe ED. On multivariate analysis, age was predictive for moderate-severe (OR=1.08, p<0.001) and severe (OR=1.09, p<0.001) ED, while vasectomy was protective against moderate-severe (OR=0.41, P<0.001) and severe (OR=0.41, p<0.003) ED. PNB status was no longer significant (p>0.05) after adjustment for other covariates. CONCLUSIONS Age is a strong predictor of ED. Prior vasectomy is associated with a reduced risk of ED. Prior PNB, after adjustment for other variables, does not increase the risk of ED. Furthermore, ED was common in this cohort, and thus patients undergoing definitive therapy for prostate cancer should be counselled appropriately prior to treatment. Seattle, WA© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e470 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Dan Lewinshtein More articles by this author Jason Kim More articles by this author Stephen Lukasewycz More articles by this author Christopher Porter More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...