Abstract
To measure the effect of a reduction of insulin concentration on ovine fetal glucose and oxygen metabolism, we measured glucose (G), insulin (I), oxygen (O2) concentrations (n=11), oxygen (O2Up) and glucose (GUp) uptakes from the placenta (n=11), glucose production (GPr) and utilization (GUt) (n=10), and glucose oxidation (GOx)(n=8) rates before and after reducing fetal insulin concentration with streptozotocin. These results demonstrate that a reduction in fetal insulin concentration results in: reduced fetal glucose utilization (p< 0.05) accounted for by a fall in both glucose oxidation (0.91 mg/min/kg) and the disposal of glucose by non-oxidative pathways (0.44 mg/min/kg); increased fetal endogenous glucose production (p< 0.01) producing hyperglycemia; and reduced fetal glucose uptake from the placenta (p < 0.001). Thus the basal level of insulin suppresses fetal endogenous glucose production, increases glucose utilization, decreases fetal glucose concentration, and increases fetal glucose uptake from the placenta.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
