Abstract
As a key regulator of hippo signaling pathway, LATS1 (large tumor suppressor 1) gene encodes a Ser/Thr protein kinase which plays a crucial role in cellular transformation and tumorigenesis. But it remains to be determined if LATS1 mutation may have true biologic relevance and can independently predict responses to immune checkpoint inhibitors (ICIs). Our research aims to elucidate its mutation association with ICI efficacy.
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