1207P - Prognostic Factors in Development of Brain Metastasis in Stage III Non-Small Cell Lung Cancer Patients After Definitive Treatment

Abstract

ABSTRACT Purpose To determine the incidence and prognostic factors of brain metastatsis in locally advanced non-small cell lung cancer (NSCLC) patients who were curatively treated. Materials and methods Curatively treated 136 patients with stage IIIA/ IIIB NSCLC between 1997-2011 were retrospectively reviewed. M/F: 112/24. Median age was 61 (36-82). Median Karnofsky Performance Scale was 80 (70-100). 61 patients (45%) were IIIA. Histology was adenocarcinoma in 27%, and squamous cell cancer in 54%. Seventy patients had concomitant or sequential chemoradiotherapy (CRT), 16% had radiotherapy (RT). All patients received platinum based chemotherapy. Median 60 Gy was administered with conformal RT. The ratio and time to brain metastasis were noted. Age, gender, stage, histology and surgery were examined as prognostic factors. Results Median follow-up was 13 months (range, 2-61 months). Two-year survival rate was 31%. One-year incidence of brain metastasis was 28.7%. In univariate analysis showed that patients younger than 60 years of age had more brain metastases than older patients (36% vs 15%, p = 0.01). Brain was more frequently the first site of metastases in younger patients than >60years (22% vs 9%, p > 0.05). Histology also significantly effected the development of brain metastasis (43.2% in adenocarcinoma, 16.4% in epidermoid carcinoma, p = 0.004). On multivariate analysis, only age was found to be significant prognostic factor (p = 0.01) Conclusion Age and histology significantly effects development of brain metastasis in locally advanced NSCLC. Younger age was the only significant variable for brain metastasis. Disclosure All authors have declared no conflicts of interest.