Abstract
Chronic lymphocytic leukemia (CLL) has long been regarded as a non-radiogenic type of leukemia. However, this standpoint has been challenged, considering the data on the increased risk of CLL development among nuclear plant workers and persons exposed to ionizing radiation (IR) due to the Chernobyl Nuclear Power Plant accident. 1 Richardson et al. Environ Health Perspect. 2005; 113: 1 Crossref PubMed Scopus (71) Google Scholar , 2 Boice et al. Radiat Res. 2011; 176: 244 Crossref PubMed Scopus (73) Google Scholar , 3 Romanenko et al. Radiat Res. 2008; 170: 711 Crossref PubMed Scopus (87) Google Scholar Our previous analysis of IGHV gene rearrangements and clinical data from 47 CLL patients exposed to IR due to the Chernobyl Nuclear Power Plant accident revealed some molecular and clinical features in groups of patients who received the largest dose of irradiation: over-representation of unmutated cases, increased usage of IGHV1-69 and IGHV3-21 genes, and a high frequency of secondary solid tumors and Richter transformation. 4 Abramenko et al. Leuk Res. 2008; 32: 535 Abstract Full Text Full Text PDF PubMed Scopus (34) Google Scholar The aim of this study was to analyze IGHV/D/J rearrangements in a larger cohort of IR-exposed CLL patients to evaluate possible peculiarities in the leukemic repertoire.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
