Abstract
This chapter focuses on time-resolved spectroscopy and enhanced near infrared (NIR) imaging using receptor-targeted contrast agents for prostate cancer detection. Two smart receptor-targeted contrast agents, Cybesin and Cytate, in aqueous solution and cancerous and normal prostate tissues were investigated using time-resolved spectroscopy. The time evolution of the fluorescence emitted from the contrast agents in solution was described using a set of first-order linear differential equations. An analytical polarization model was developed and used to extract rotational times and fluorescence anisotropies of the contrast agents in prostate tissues. Differences of rotational times and polarization anisotropies were observed for Cybesin (Cytate) in cancerous and normal prostate tissue, due to the preferred bonding of contrast agents with cancerous tissue cells, which offers high-contrast smart agents for imaging and distinguishing cancerous prostate tissues from normal tissues.
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