12 - Investigating the Contribution of the HNF-1αG319S Gene Variant to Early-Onset Type 2 Diabetes Using MIN6 β-Cells and Mice

Abstract

Forty per cent of Manitoban Indigenous youth with type 2 diabetes (T2D) harbour the HNF-1αG319S variant. Among carriers, clinical evidence implicates pancreatic β-cell dysfunction compounded by modern dietary stress. We hypothesize that the G319S variant alters β-cell metabolism and insulin secretion in a macronutrient-dependent manner.