Abstract

This chapter discusses the target of rapamycin (TOR) signaling in Chlamydomonas reinhardtii . Cell growth is tightly coupled to favorable nutrient conditions. The TOR kinase transmits nutritional and environmental cues to the cellular growth machinery. TOR functions in two distinct multiprotein complexes termed “TORC1” and “TORC2,” and core components of these complexes are evolutionarily conserved like TOR. The TOR pathway controls cell growth by promoting anabolic processes, including protein synthesis and ribosome biogenesis, and inhibiting catabolic processes such as autophagy. The TOR kinase has been identified in plants and microalgae, indicating that this signaling pathway is conserved in photosynthetic eukaryotes. The central role that these organisms, particularly microalgae, play in global biomass production, together with their high biotechnological potential in biofuel generation, has recently boosted basic research focused on cell growth improvement. The chapter also reviews recent advance in the study of the growth controller TOR pathway from the unicellular green alga Chlamydomonas reinhardtii .

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