Abstract
Objective To evaluate the hysteresis of 125 Ⅰ antiAFP antibody infused via hepatic artery combined with TACE in patients with HCC,and the effect and toxicity were observed.Methods In targetting therapy group (36 cases), 125 Ⅰ antiAFP antibody was given as an intrahepatic artery infusion combined with TACE.34 cases reseived TACE alone group.Results Medium radioactive ratio of tumor/liver was 1 86±0 72 after targetting therapy.Response rate (PR+MR) were 55 6% and 41 2% for targetting therapy group and TACE alone group,respectively ( P 0 05).Markedly reduced rate of serm AFP level and medium duration of response were 77 8% and 8 5%M for targetting therapy group and 52 9% and 5 6M for TACE alone group,respectively ( P 0 05).Transient hypothyronine T 3 and T 4 occurred in 16 7% cases of targetting therapy group.The other toxicities were tolerable and similar in two groups.Conclusion 125 Ⅰ antiAFP antibody infusion via hepatic artery combined with TACE have a specific retentionist in the tumor mass.The efficacies of complex therapy were better than TACE alone for HCC,and the toxicities were tolerable.
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