12.5 Efficacy and Safety of Second-Generation Antipsychotics in Youth With Bipolar Depression

Abstract

Depression associated with bipolar disorder in youth is associated with high rates of suicide attempts and significant functional impairment. Three prior studies have examined the efficacy of second-generation antipsychotic (SGA) drugs in youth with bipolar depression. However, findings from these studies have yielded mixed results. We will present findings from a recent study evaluating the efficacy and safety of lurasidone in youth with bipolar depression and will discuss these results in the context of previous studies of SGAs in youth with bipolar depression.