1,1-Dimethylallylcoumarins potently supress both lipopolysaccharide- and interferon-γ-induced nitric oxide generation in mouse macrophage RAW 264.7 cells

Akira Murakami,Guanxin Gao,Mitsuo Omura,Masamichi Yano,Chihiro Ito,Hiroshi Furukawa,Daisuke Takahashi,Koichi Koshimizu,Hajime Ohigashi

doi:10.1016/s0960-894x(99)00578-8

1,1-Dimethylallylcoumarins potently supress both lipopolysaccharide- and interferon-γ-induced nitric oxide generation in mouse macrophage RAW 264.7 cells

Akira Murakami, Guanxin Gao + Show 7 more

https://doi.org/10.1016/s0960-894x(99)00578-8

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Journal: Bioorganic & Medicinal Chemistry Letters	Publication Date: Jan 1, 2000
Citations: 105

Affiliation: Kindai University, Kyoto University, Institute of Fruit Tree and Tea Science, Shimizu (Japan), Meijo University

#Nitric Oxide Generation #Inhibited Nitric Oxide Generation + Show 8 more

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Abstract

We investigated the suppressive effects of 16 coumarin-related compounds on both lipopolysaccharide (LPS)- and interferon (IFN)-γ-induced nitric oxide (NO) generation in a mouse macrophage cell line, RAW 264.7. Notably, coumarins possessing prenyl unit(s) were found to be highly active, a tendency consistent with our previous study. Among the coumarins tested, 1,1-dimethylallylcoumarins showed the highest inhibitory activity. Western blotting analysis revealed that they inhibited NO generation by suppressing inducible NO synthase (iNOS) protein expression. Our ongoing studies suggest that coumarins are prominent natural compounds that attenuate excessive and prolonged NO generation at inflammatory sites.

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