Abstract
BackgroundActivation of glial cells is a cardinal feature in multiple sclerosis (MS) pathology, and acetate has been reported to be selectively uptaken by astrocytes in the CNS. The aim of this study was to investigate the efficacy of PET with 11C-acetate for MS diagnosis.Materials and MethodsSix patients with relapsing-remitting MS and 6 healthy volunteers (HV) were enrolled. The 11C-acetate brain uptake on PET was measured in patients with MS and HV. Volume-of-interest analysis of cerebral gray and white matter based on the segmentation technique for co-registered MRI and voxel-based statistical parametric analysis were performed. Correlation between 11C-acetate uptake and the lesion number in T1- and T2- weighted MR images were also assessed.ResultsThe standardized uptake value (SUV) of 11C-acetate was increased in both white and gray matter in MS patients compared to HV. Voxel-based statistical analysis revealed a significantly increased SUV relative to that in the bilateral thalami (SUVt) in a broad area of white matter, particularly in the subcortical white matter of MS patients. The numbers of T2 lesions and T1 black holes were significantly correlated with SUV of 11C-acetate in white and gray matter.ConclusionsThe 11C-acetate uptake significantly increased in MS patients and correlated to the number of MRI lesions. These preliminary data suggest that 11C-acetate PET can be a useful clinical examination for MS patients.
Highlights
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease of the CNS [1]
The standardized uptake value (SUV) of 11C-acetate was increased in both white and gray matter in multiple sclerosis (MS) patients compared to healthy volunteers (HV)
In the CNS, 11C-acetate PET has proven useful for the diagnosis of astrocytoma [14] because acetate is preferentially absorbed into astrocytes by the monocarboxylate transporter (MCT) [15,16]
Summary
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease of the CNS [1]. 11C-acetate has been used as a tracer to evaluate cardiac oxidative metabolism [9] and later used as a PET biomarker in patients with renal cell carcinoma, hepatocellular carcinoma, prostate cancer, and multiple myeloma [10,11,12,13]. In the CNS, 11C-acetate PET has proven useful for the diagnosis of astrocytoma [14] because acetate is preferentially absorbed into astrocytes by the monocarboxylate transporter (MCT) [15,16]. We surmised that 11Cacetate PET could be a useful diagnostic tool in combination with MRI, and we investigated the utility of 11C-acetate PET for the diagnosis of MS and evaluated the astrocyte activity in the MS brain. Activation of glial cells is a cardinal feature in multiple sclerosis (MS) pathology, and acetate has been reported to be selectively uptaken by astrocytes in the CNS. The aim of this study was to investigate the efficacy of PET with 11Cacetate for MS diagnosis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
